Coronary artery disease is a progressive generalised disease involving entire arterial tree of the individual. Means,
though it is labelled as coronary artery disease, it is not only blockages of coronary arteries, entire arterial tree is getting blocked with blockages with blood cells, lipids and other debris. Coronary arteries supply blood to myocardium. Any obstruction to coronary arteries deprive blood to heart cells, lacking nutrition & oxygen supply,causing heart attack & death depending on severity of the attack.Many factors such as sex, age, hypertension, heredity,diabetes, sedentary life style, obesity, stress, fatty diet, smoking & alcohol drinking are major risk factors. Coronary artery bypass surgery or angioplasty are palliative surgical procedures which give temporary relief to CAD patients, where 100%recurrence is inevitable.In addition to this, entire arterial tree give low perfusion to end organs due to high viscosity of blood in CAD patients.Using diseased saphenous vein, mammary arteries as conduits to bypass the diseased arteries in coronary artery bypass surgery is useless surgical procedure as patient has to come for re-do surgery.Baruah applied human Genetic engineering targets diseased microRNA responsible for CAD and cure the disease without bypass surgery.
